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New Dataset: A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention
Pancreatic ductal adenocarcinoma (PDAC) often spreads to the liver early, leaving most patients with only palliative chemotherapy. This study found that as PDAC cells [...]
New Dataset: A Heparan-Sulfate-Bearing Syndecan-1 Glycoform Marks Immunosuppressive Cells Inside Tumors
Myeloid-derived suppressor cells (MDSCs) help tumors dodge the immune system, but they're hard to target: inside a tumor, they look almost identical to mature, [...]
New Dataset: Distinct Mouse Models of Stargardt Disease Reveal Different Responses to Pharmacological Targeting of Ceramides and Inflammation
Stargardt disease is the most common inherited cause of macular degeneration, but patients who lose the same gene, ABCA4, don't all lose their vision [...]
New Dataset: Visualizing Programmed Lineage Trajectories at Cancer Initiation
Screening and treating early breast lesions (DCIS) hasn't done much to lower breast cancer deaths, a sign that some tumors are already headed down [...]