Highlights of new data, tools and resources on the Cancer Complexity Knowledge Portal
After severe trauma like burns, some patients grow bone inside muscle and tendon, a painful condition called heterotopic ossification (HO). It starts when mesenchymal [...]
HER2-positive breast cancers are treated as one group, yet they're among the most varied subtypes, and that variety usually takes shape before tumors can [...]
Pancreatic ductal adenocarcinoma (PDAC) often spreads to the liver early, leaving most patients with only palliative chemotherapy. This study found that as PDAC cells [...]
Myeloid-derived suppressor cells (MDSCs) help tumors dodge the immune system, but they're hard to target: inside a tumor, they look almost identical to mature, [...]
Stargardt disease is the most common inherited cause of macular degeneration, but patients who lose the same gene, ABCA4, don't all lose their vision [...]
Screening and treating early breast lesions (DCIS) hasn't done much to lower breast cancer deaths, a sign that some tumors are already headed down [...]
Pancreatic cancer kills about 90% of patients, mostly because it spreads to other organs. This dataset helps explain how. Researchers found that aggressive pancreatic [...]
More than 10 million cancer mutations in TCGA have no known functional effect. Rather than characterizing each one experimentally, this dataset uses transcription factor [...]
One of the persistent problems in AML is that leukemia cells don't all die from chemotherapy; some survive, go quiet, and eventually drive relapse. [...]
Immune cells called macrophages make up a large chunk of a glioblastoma tumor — and they help it grow, hide from treatment, and resist [...]
