Featured Dataset: Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

This study highlights the RNA sequencing and whole exome sequencing data associated with the investigation of a model neoantigen (neoAg) from murine melanoma and its cognate TCR. The research demonstrates that a specific mutation enhances MHC-I binding, improving antigen presentation and TCR stability. These findings underscore the importance of molecular and structural analyses of neoAg, supported by RNA and exome sequencing data, to better understand neoAg immunogenicity and TCR interactions across diverse MHC-I contexts.