One of the persistent problems in AML is that leukemia cells don’t all die from chemotherapy; some survive, go quiet, and eventually drive relapse. This dataset was built to understand one mechanism behind that survival. In chemoresistant cells, glutamine metabolism spikes transiently after treatment, a shift that appears to help cells persist under stress.
To track the gene expression changes driving this, RNA-seq was performed on GFP+ leukemia cells pulled from mouse bone marrow at three time points: before treatment, 3 days post-induction chemotherapy, and 10 days out, at relapse. The data cover that full window — from initial response through recurrence — and may point to metabolic dependencies worth targeting.
